National Repository of Grey Literature 2 records found  Search took 0.01 seconds. 
Determination of selected drugs (beta-bloskers) in surface water
Kříž, Jiří ; Zlámalová Gargošová, Helena (referee) ; Vávrová, Milada (advisor)
This bachelor's thesis discusses the issue of pharmaceuticals in the environment. -blockers are one of the most prescribed medications with the most frequent detection in the environment. These compounds are clinically important drugs used to cure cardiovascular disorders such as hypertension, arrythmia and angina pectoris. Due to their acute and chronic toxicity towards aquatic organisms it is important to monitor the concentrations levels. This study is focused on optimization of analytical method to determine these compounds. The matrix examined was a waste water from a waste water treatment plant (WWTP) Brno Modřice. A solid-phase extraction (SPE) was used for the isolation of analytes in a waste water samples. A method of high performance liquid chromatography (HPLC) with the UV-VIS detection using a diode array detector (DAD) and mass spectrometry (MS) was used. Target analytes were atenolol, metoprolol and bisoprolol.
Determination of selected drugs (beta-bloskers) in surface water
Kříž, Jiří ; Zlámalová Gargošová, Helena (referee) ; Vávrová, Milada (advisor)
This bachelor's thesis discusses the issue of pharmaceuticals in the environment. -blockers are one of the most prescribed medications with the most frequent detection in the environment. These compounds are clinically important drugs used to cure cardiovascular disorders such as hypertension, arrythmia and angina pectoris. Due to their acute and chronic toxicity towards aquatic organisms it is important to monitor the concentrations levels. This study is focused on optimization of analytical method to determine these compounds. The matrix examined was a waste water from a waste water treatment plant (WWTP) Brno Modřice. A solid-phase extraction (SPE) was used for the isolation of analytes in a waste water samples. A method of high performance liquid chromatography (HPLC) with the UV-VIS detection using a diode array detector (DAD) and mass spectrometry (MS) was used. Target analytes were atenolol, metoprolol and bisoprolol.

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